Posters

HLA association with Acetaminophen-related Stevens-Johnson syndrome with severe ocular complications in Japanese

Poster Details

First Author: M.Ueta JAPAN

Co Author(s): R. Yoshiro Saito   C. Toshio Yabe   K. Shigeru Kinoshita              

Abstract Details

Purpose:

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute-onset mucocutaneous diseases induced by infectious agents and/or inciting drugs. We have reported that the main causative drugs for SJS/TEN with severe ocular complications (SOC) were cold medicines including multi-ingredient cold medications and non-steroidal anti-inflammatory drugs (NSAIDs) to combat the common cold. Moreover, we also reported that acetaminophen is a most frequent causative drug in various cold medicines. In this study, we focused on acetaminophen related SJS/TEN with SOC and analyzed not only HLA-class I (HLA-A, B, C), but also HLA-class II (HLA-DRB1, DQB1).

Setting:

Case-Control study

Methods:

We studied the histocompatibility antigen genes HLA-A, B, C, DRB1, and DQB1 of 80 Japanese acetaminophen related SJS/TEN with SOC. We also genotyped 113 healthy volunteers for HLA-A, B, C, DRB1, and DQB1. We performed polymerase chain reaction amplification followed by hybridization with sequence-specific oligonucleotide probes (PCR-SSO) using commercial bead-based typing kits.

Results:

HLA-A*02:06 was strongly associated with acetaminophen related SJS/TEN with SOC (carrier frequency: p=8.01×10-7, Pc=7.21×10-6, OR=5.4; gene frequency: p=1.13×10-6, Pc=1.02×10-5, OR=4.1). HLA-A*11:01, B*52:01 and C*12:02 were inversely associated, and HLA-B*13:01, DRB1*08:03 and DRB1*12:02 were also associated although the results ceased to be significant when we corrected the p-value for the number of alleles detected.

Conclusions:

Acetaminophen related SJS/TEN with SOC was strongly associated with HLA-A*02:06 in Japanese, but not associated with HLA-class II (HLA-DRB1, DQB1).

Financial Disclosure:

None