Posters

Plasma rich in growth factors in the treatment of complex corneal disorders

Poster Details

First Author: N.Palarie MOLDOVA

Co Author(s): T. Pasenco   V. Palarie                 

Abstract Details

Purpose:

Plasma rich in growth factors (PRGF) is an autologous blood product rich in proteins and growth factors which can be rapidly obtained from patient blood. Clinically, it is an affordable treatment with potentially broad spectrum of applications in ophthalmology especially in the treatment of complex or refractory corneal wounds. The aim of this study was to evaluate the efficiency of autologous platelet-rich plasma in the treatment of complex corneal disorders.

Setting:

The study was performed at the Ophthalmology Department of International Clinic, Orhei, Moldova in January - October 2019.

Methods:

There were 29 patients with corneal surface disorders, among which 8 patients with chemical burns, 8 patients with corneal ulcers, 6 with neurotrophic keratopathy and 7 with non-healing epithelial corneal defect after pterygium surgery. Visual acuity varied from hand motion to 0.1. Solid PRGF was either just placed on the corneal surface or sutured with 2 nodes of 10-00 nylon suture at conjunctiva. If necessary, the procedure was repeated. All patients had corneal OCT scan before and after the treatment.

Results:

Improved visual acuity and less subjective symptoms were observed in all patients. Complete healing of cornea was observed in all patients with chemical burns. As well considerable improvement experienced 7 of 8 patients with corneal ulcers (reduced size and depth of the ulceration, improved visual acuity, smaller conjunctival injection). Also an improvement was seen in 2 of 4 patients with neurotrophic keratopathy. None of the patients reported general or local side effects of the treatment.

Conclusions:

PRGF is a reliable and effective therapeutic tool to promote wound healing in complex corneal disorders.

Financial Disclosure:

None