Posters

Five-year follow-up of corneal thickness spatial profile and corneal volume distribution changes after uneventful DMEK

Poster Details

First Author: A.Lazaridis GERMANY

Co Author(s): B. Spiru   E. Giallouros   F. Schroeder   W. Sekundo   K. Droutsas        

Abstract Details

Purpose:

To investigate changes of corneal thickness spatial profile (CTSP) and corneal volume (CV) distribution over a course of 5 years after uneventful Descemet membrane endothelial keratoplasty (DMEK)

Setting:

Department of Ophthalmology, Philipps University of Marburg, Germany

Methods:

Medical records of 212 consecutive surgeries were reviewed. Sixty cases without intraoperative and postoperative complications and with complete 5-year follow-up were included (group 1). CTSP at corneal apex (CCT) and at 2mm, 4mm, 6mm and 8mm rings around the thinnest point (MCT) and CV in 3mm, 5mm, 7mm and 10mm zones were evaluated preoperatively and at 3, 6, 12, 24 and 60 months postoperatively. The 60-month results were compared to an age-matched group of uncomplicated pseudophakic eyes (group 2; n=20).

Results:

The CCT, MCT, and CTSP at 2, 4 and 6mm increased significantly at 5 years compared to 3-month outcomes (P=0.000). CV decreased significantly in all zones at 3 months (P=0.000), followed by a significant increase at 5 years in 3, 5 and 7mm zones (P=0.000). The 5-year CCT, MCT and CTSP at 2mm were similar to group2 (P≥0.111), but CTSP at 4, 6, and 8mm were significantly higher after DMEK (P≤0.023). The 5-year CV at 3mm was similar to group2 (P=0.119), but CV at 5, 7 and 10 mm zones was significantly increased (P≤0.043).

Conclusions:

Sixty months after uneventful DMEK, CT within the central 2mm zone and CV at 3mm zone were similar to uncomplicated pseudophakic eyes. There was, however, a continuous and significant increase of CTSP and CV distribution towards the periphery over the 5-year postoperative course.

Financial Disclosure:

None