Posters

Long term treatment failure rate after accelerated collagen cross-linking therapy

Poster Details

First Author: M.Hamza UK

Co Author(s): K. Namjoshi   L. Papaioannou   V. Zygoura   A. Konstantopoulos   P. Hossain   D. Anderson     

Abstract Details

Purpose:

Keratoconus is a corneal ectatic condition causing the cornea to protrude and thin leading to a conically shaped cornea. A variety of protocol has been used to halt its progression, such as the gold standard Dresden protocol or the accelerated collagen crosslinking. This retrospective audit we show the effectiveness of the accelerated treatment utilising UVA radiation of 9mW directed at the cornea for 9 minutes; in comparison to the NICE guideline IPG466.

Setting:

University Hospital Southampton UK

Methods:

An audit of patient records conducted on Pentacam scanner of those diagnosed with keratoconus and underwent the accelerated collagen cross-linking treatment. Exclusion criteria: lost to post-operative follow-up, no pre-operative pentacam, history of active anterior corneal conditions and previous corneal surgery of the anterior aspect of the eye. Outcome Measures collected include best corrected visual acuity (BCVA), pre-op and post-op data of keratometry values, complications, and corneal thickness.

Results:

202 eyes,170 patients were included with a followup 24 months.A paired t-tests found a statistically significant improvement in mean BCVA, K1, K2, Kmax, pachy apex and thinnest patch.Mean reduction of K1 (0.25±5.72D) & K2 (0.37±1.66D) & Kmax (0.95±4.17D).The thinnest patch on the cornea has decreased by 10μm.Kmean, posterior K2 and corneal astigmatism were not statistically significant.Wilcoxon Signed-rank test assessing mean K2 and Kmax found Grade 1 Kmax and Grade 2 K2 and Kmax to be statistically significant. Few complications were present,62.4% of patients treated had pre-existing corneal pathology,3% developed haze and 0.5% either keratitis, conjunctivitis or raised IOP

Conclusions:

Corneal collagen cross-linking using the accelerated protocol have shown to have positive results on halting the progression of keratoconus. It has shown to improve BCVA, keratometry readings with few complications.

Financial Disclosure:

None