Posters

Trauma-induced exacerbation of Lish-like superficial corneal changes

Poster Details

First Author: D.Darsova CZECH REPUBLIC

Co Author(s): D. Baráková                    

Abstract Details

Purpose:

To present a rapid progression of trauma-induced superficial corneal changes resembling Lish´s dystrophy in a healthy eye of a 70-year-old patient.

Setting:

Retrospective case report

Methods:

Patient underwent full ophthalmic examination. Subsequent surgery, epithelial abrasion with Mitomycin C (0.4 mg/ml, Nordic Pharma,Czech Republic) and mechanical straightening of the basal membrane (BM), was performed in a standard way under topical anesthesy. Genetic testing was conducted on epithelial cells collected from the inner cheeks. Genomic DNA was extracted with a DNA blood mini kit. Genetic testing was focused on eliminating the positivity of Transforming Growth Factor Beta I (TGFBI) gene mutation. Permission to publish clinical finding was obtained from a patient.

Results:

A 70-year-old male presented with the symptom of decreased visual acuity (VA) to 0.8 on his left eye two months after a tree branch injury. Slit lamp examination revealed paracentral superficial corneal feather-shaped opatities arranged in a whorled pattern. His family history was negative. His right eye demonstrated three fingerprint lines opatities. Due to the superficial corneal changes progression with decreased VA to 0.4 five months later, he underwent surgery. BM disruption at the site of injury was apparent. Genetic testing revealed no TGFBI gene mutation. Normal VA with triangular shaped corneal scar is present nine months after the surgery.

Conclusions:

Patient in our case was asymptomatic until he sustained trauma to his eye. He had unilateral presentation of Lish´s dystrophy like superficial corneal changes with visual rehabilitation through epithelial abrasion with Mytomicin C. Genetic TGFBI gene testing excluded more frequent superficial corneal dystrophies. Most traumatic erosions heal without sequelae. In our case, it was atypical corneal healing under the image of Lish´s dystrophy.

Financial Disclosure:

... gains financially from competing product or procedure, ... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, ... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, ... receives non-monetary benefits from a company producing, developing or supplying the product or procedure presented, ... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented, ... is employed by a competing company, ... has significant investment interest in a company producing, developing or supplying product or procedure presented