Posters

Neurotrophic corneal ulcer following the use of non-steroidal inflammatory eye drops

Poster Details

First Author: S.Bousseta MOROCCO

Co Author(s): J. Ait El Haj   A. Mchachi   L. Benhmidoune   A. Chakib   R. Rachid   M. El Belhadji     

Abstract Details

Purpose:

Neurotrophic keratitis (NK) is a rare degenerative corneal disease caused by damage of trigeminal innervation Non steroidal anti-inflammatory drugs (NSAIDs) are used widely for systemic control of acute or chronic pain and inflammation. We report the case of a patient who presented with a neurotrophic corneal ulcer following the use of indomethacin eye drops. the purpose is to report corneal complications associated with topical non steroidal anti-inflammatory drugs .

Setting:

Adult ophtalmology department, Hospital 20 Agust 1953,  University  Hospital Center IBN ROCHD , Faculty of medicine and pharmacy, University HASSAN II, Casablanca

Methods:

this  case concerns  a  62-years-old patient who received indomethacin for 2 weeks after yag laser capsulotomy.the patient was  received for a red eye with reduced visual acuity (VA).

Results:

The clinical examination found a limited VA to hand movement, a corneal ulcer of 4mm on 3mm with  corneal sensitivity abolished . The patient was put on oral antibiotics and antiviral treatment, local antibiotics therapy and wetting agents. the clinical examination yielded  the same a priori results. The patient was subsequently placed under autologous serum with all potentially toxic eye drops stopped. The evolution was marked by a decrease in the size of the ulcer with persistence of a central stromal scar responsible for a weak visual recovery.

Conclusions:

The use of certain eye drops is responsible for a decrease in corneal sensitivity, particularly nonsteroidal anti-inflammatory drugs or NSAID The frequency of administration and duration of treatment should be minimized, and as-needed use should be discouraged. A history of ocular surface disease associated with an increased risk of corneal melting is a relative contraindication for topical NSAID use.All topical and systemic medications associated with ocular surface toxicity should be discontinued. Preservative-free tear substitutes and lubricant ointments are useful to improve lubrication and ocular surface health. Autologous serum eye drops have become increasingly popular for treating ocular surface disorders.

Financial Disclosure:

... gains financially from product or procedure presented