Corneal and ocular surface characterization in ocular graft vs host disease

Session Details

Session Title: Moderated Poster Session: What News from Cornea?
Session Date/Time: Saturday 22/02/2020 | 14:00-15:00
Paper Time: 14:24
Venue: Poster Area


First Author: C.Alba Linero SPAIN
Co Author(s): C. Rocha de Lossada  S. Lozano Ruiz  C. Gómez Cabrera  M. Rodríguez Calvo de Mora        

Abstract Details

Purpose:

To characterize anatomical and functional changes in the ocular anterior segment after stem cell transplantation.

Setting:

Ophthalmology Department, Hospital Regional Universitario Málaga (Spain).

Methods:

Three groups of patients were included. Group 1: patients who had undergone allogeneic stem cell transplantation (HSCT) (n=26). Group 2: patients who developed chronic graft versus host disease (GvHD) after HSCT (n=14). Group 3: healthy subjects (n=20). A complete ophthalmological examination was undertaken in all subjects, including Schirmer test, BUT (break-up-time) test, Oxford scale, OSDI test, corneal tomography and conjunctival CD8+ lymphocyte detection. Three branches of work were created: Branch 1(comparative analysis before and after HSCT in Group 1), Branch 2 (comparative analysis between Group 2 and 3), Branch 3 (comparative anaylsis between Group 1 after HSCT and Group 2)

Results:

In Branch 1, statistically significant differences were found in following variables: best-corrected visual acuity (BCVA) OD (p=0.08), OSDI test (p=0.003), BUT OU (OD p=0, OS p=0.0003), Oxford test OU (OD p=0.01, OS p=0.0049) and CD8+ lymphocytes OU (OD p=0.003, OS p=0.01). In Branch 2, the variables with statistically significant differences (p<0.001)in OU were: BCVA, OSDI test, Schirmer test OU, BUT test, Oxford test and CD8+ lymphocytes. Finally, in Branch 3, statistically significant differences (p< 0.001) were found OU: in OSDI test, Schirmer test and Oxford test OU; and with p<0.005 in BUT test OU.

Conclusions:

In our study, statistically significant changes were observed in the OSDI test, BUT test, Oxford Scale and the detection of CD8+ lymphocytes in patients that underwent HSCT. Differences were more significant in those patients who had developed GvHD after HSCT compared to those without GvHD.

Financial Disclosure:

None