Evaluation of corneal neovascularization using optical coherence tomography angiography (6 eyes)

Session Details

Session Title: Moderated Poster Session: What News from Cornea?
Session Date/Time: Saturday 22/02/2020 | 14:00-15:00
Paper Time: 14:08
Venue: Poster Area


First Author: H.Tazi MOROCCO
Co Author(s): Y. Akannour  A. Bouslamti  A. Er-Radi  F. Hjira  E. Abdellah  A. Berraho  

Abstract Details

Purpose:

Corneal neovascularization is one of the main causes of corneal blindness. The use of Optical Coherence Tomography Angiography (OCT-A) for the analysis of ocular surface neovessels is currently at an experimental stage. Through this work we evaluate the advantages of Optical Coherence Tomography-Angiography in the detection of corneal neovessels, their depth and signs suggestive of activity / quiescence compared to Fluorescein Angiography.

Setting:

06 eyes with corneal neovessels were recruited prospectively at the Department of Ophthalmology B of the Specialty Hospital- Rabat between June 2018 and February 2019. All patients underwent OCT-A and Fluorescein Angiography at a two-week interval. The tomographic images were correlated with the depth of corneal neovascularization.

Methods:

06 patients were included in the study, the age of our patients varied from 16 years to 62 years, 3 patients had sequelae of bacterial keratitis, 2 patients had corneal neovessels caused by herpes and in one patient by a corneal wound. Time to progression was less than 1 month in 2 patients, and more than 6 months in 2 patients. On angiography, the average time of neovessel appearance was 31 seconds. Neovessels evolving since less than a month showed an early diffusion of around 30 seconds.

Results:

The results of OCT-A were consistent with data from Fluorescein Angiography by showing characteristics of immature neovessels in those with an early diffusion, it allowed the study of the structure: trunk, number of segments and fractal divisions, the existence of the apical loop. As well as the detection of the flow level.Few studies have evaluated OCT-A in the evaluation of corneal neovessels. Our initial analyses suggest that scans provide better penetration and better resolution of corneal neovessels. The existence of important fractal divisions, a large diameter and apical loops are activity criteria.

Conclusions:

Monitoring can be done subjectively on the appearance and flow detected or objectively by evaluating the neovascular surface through external software. This innovative technique is promising for the delineation of corneal neovessels. Future improvements of the software and optimization for the anterior segment acquisition could still reduce artifacts and improve the image resolution.

Financial Disclosure:

None