Evaluation of retinal ganglion cells function measured by pattern electroretinogram (pERG) after femtosecond laser assisted LASIK (FS-LASIK)

Session Details

Session Title: Refractive
Session Date/Time: Friday 21/02/2020 | 08:15-10:10
Paper Time: 09:14
Venue: Fes 1.

First Author: S.Ketabi Shadvar SPAIN
Co Author(s): E. Arranz-Marquez  G. Laucirica  M. Garcia-Gonzalez  M. Teus        

Abstract Details

Purpose:

To analyze the effect of femtosecond laser assisted LASIK (FS-LASIK) on the electric response of retinal ganglion cells using pattern electroretinogram (pERG).

Setting:

Clinica Novovision, Madrid, Spain.

Methods:

This was an observational, prospective cohort study, that included myopic patients that have consecutively undergone FS-LASIK(IntraLase®J&J)for less than 6 diopters of myopia and less than 2 diopters of astigmatism correction.We excluded patients with diabetes, retinal or neuroophthalmological pathologies;also, those with an excessive blinking or tearing, or patients with 1 day postoperative uncorrected visual acuity less than 0.9 (Snellen).Diopsys NOVA®(Diopsys Inc., NJ)pERG records, using high and low contrast patterns, were obtained 24hours and 1 month after FS-LASIK was performed.We analyzed the Magnitude(μV),Magnitude D(μV), ratio Magnitude D/Magnitude, and signal-to-noise ratio(dB).Wilcoxon test for nonparametric paired data was employed.

Results:

We analyzed pERG data from 24 eyes from 24 different patients, that underwent FS- LASIK. 41% were men. Mean age was 35.79±9.86 years. Mean preop myopic refraction was -2.69±7.6D and -0.38±0.40D of astigmatism. Mean surgery time was 56.88±7.6 seconds. No statistically significant differences were obtained for any of the studied parameters when comparing 24h with 1 month post FS-LASIK, with the exception of Magnitude at low contrast, that increased from 1.21±0.2 µV to 1.39±0.29 µV, at 24h and 1 month post-op, respectively (p=0.03).

Conclusions:

Femtosecond assisted LASIK seems to induce a mild and transitory defect in retinal ganglion cell function. We have only detected a mild decrease in the Magnitude value for low contrast stimuli when pERG was performed at 24 hours postoperatively, then it recovers 1 month after the surgery.

Financial Disclosure: