Posters

Treatment of HSK combined with corneal perforation or impending perforations with acellular porcine cornea stroma graft

Poster Details

First Author: X.Jin CHINA

Co Author(s):                        

Abstract Details

Purpose:

To evaluate the results of using acellular porcine cornea stroma in Treatment of HSK combined with corneal perforation or impending perforations in emergency situation or shortage of�Â� cornea�Â� donors.

Setting:

Patients suffered HSK combined with Corneal melting with corneal perforation or impending perforations were included in this study from eye center of the second affiliated hospital Zhejiang University School of Medicine .

Methods:

Corneal perforations were treated by double lamellar keratoplasty. First,�Â� perforation�Â� was repaired using dissected lamellar piece from the same patient health cornea area, 1 mm larger than the�Â� perforation, after which one more acellular porcine corneal stroma (APCS) graft was transplanted to treat the ulcer. Corneal impending perforations were treated by deep lamellar keratoplasty with APCS graft. Corneal photography, anterior OCT, visual acuity and NCT were documented at each follow-up visit. Epithelialization of APCS graft and any changes and adverse events were recorded to demonstrate the safety and efficacy of APCSs in human keratoplasty.

Results:

Twelve cases of HSK combined with Corneal melting with corneal perforation or impending perforations were enrolled in this study. Visual improvement was achieved in nine cases. �Â� Epithelialization occurred in all APCS grafts. The sealing of the�Â� perforation�Â� and the re-establishment of the anterior chamber were achieved successfully in all perforations cases.�Â� Two cases presented APCS graft melting because of the reoccurrence of HSK at month 9 and month 12. Two cases presented partly suture loose and neo-vascularization which solved by suture removed and anti-inflammation treatment. �Â� No other severe adverse reaction or any significant change in postoperative fellow up.

Conclusions:

APCS lamellar keratoplasty seems to be effective in the treatment of corneal perforations. This technique solves the problem of shortage in supplying corneas and can be used in an emergency.

Financial Disclosure:

NONE