Unexpected potential protective effect of ozone in association between outdoor air pollution and cataract
Session Details
Session Title: Presented Poster Session: Quality of Vision/Miscellaneous
Venue: Poster Village: Pod 3
First Author: : D.Kim SOUTH KOREA
Co Author(s): : M. Kim M. Kim W. Wee
Abstract Details
Purpose:
To investigate associations between outdoor air pollution and cataract in the Korean general adults
Setting:
A population-based cross-sectional study using the Korea National Health and Nutrition Examination Survey data (from July 1, 2008 to December 31, 2012). 18,622 adults more than 40 years old were included. Whole analyses were performed in Gachon University Gil Medical Center.
Methods:
Outdoor air pollution factors [humidity, particulate matter (PM), ozone (O3), nitrogen dioxide (NO2), and sulfur dioxide (SO2) concentrations for 2 years prior to the ocular examinations] were collected from national monitoring stations. Associations of multiple air pollutants with the presence of cataract or each subtype were assessed from multivariate logistic regression analyses. Sociodemographic factors and previously known affecting factors to cataracts were controlled as covariates. (model 1 includes sociodemographic factors, model 2 includes sociodemographic and clinical factors) Distributed lag models were additionally used for estimating cumulative effects of air pollution on cataracts.
Results:
Higher O3 concentrations for 2 years prior to the examinations were negatively associated with cataract [0.003ppm increase - model 1: (OR: 0.85, p=0.017), model 2: (OR: 0.80, p=0.003)], and especially showed a protective association with nuclear cataract subtype. [0.003ppm O3 increase - model 1: (OR: 0.75, p=0.001), model 2: (OR: 0.70, p<0.001)] Distributed lag models also presented that higher O3 levels were negatively associated with cataract and nuclear cataract subtype. [cataract - for year lag 1/lag 2: model 2 (OR: 0.84/0.83) / nuclear cataract for year lag 1/lag 2: model 2 (OR: 0.77/0.78), all p<0.017]
Conclusions:
Higher O3 concentrations showed a protective association with cataract and nuclear cataract subtype in the Korean population.
Financial Disclosure:
NONE
