Posters

Histopathological corneal changes as an indicator for prognosis of penetrating keratoplasty in patients with corneal scar

Poster Details

First Author: S.Tomar INDIA

Co Author(s):    P. Mathur   C. Jindal                 

Abstract Details

Purpose:

To identify histopathological changes in corneal button with corneal scar after healed microbial keratitis which underwent optical penetrating keratoplasty.

Setting:

Department of Ophthalmology, National Institute of Medical Sciences and Hospital, NIMS University, Jaipur, India.

Methods:

Clinical study of 50 patients who presented with healed corneal scar 6 months to 1 year after healing of active microbial keratitis and had penetrating keratoplasty.Haematoxylin and eosin stain done on corneal buttons & examined under 40 X magnification.

Results:

Analysed group consisted of 33 men & 17 women.Average age of patients was 51.42+16.75 years .Irregularity of epithelium was seen in 48 corneal button.Cellular infiltration comprising of mononuclear cells( lymphocytes & plasma cells) in 47 corneas .Cellular infiltration with vascularisation was in 26 corneas.Other finding included patchy loss of Bowman’s layer and diffuse fibrosis.

Conclusions:

Presence of neovascularisation & inflammation on histopathology shows that tissue was in stage of inflammation & not regeneration at the time of transplantation and thus would require different approach of treatment post transplant to prevent complications.

Financial Disclosure:

NONE