Posters

Trabeculectomies and tube shunts: Mitomycin C, 5 Fluorouracil and other perioperative therapeutics

Poster Details

First Author: M.Bodman USA

Co Author(s):                        

Abstract Details

Purpose:

To describe the use of adjunctive therapeutics used in traditional filtration surgeries. To discuss optimization of antimetabolite, anti fibrotic and anti-VEGF effects for successful functioning filtering blebs against risks factors, which contribute to surgical failure in glaucoma surgeries.

Setting:

Ophthalmology Section, Department of Surgery,North Las Vegas Veterans Affairs (VA) Medical Center, North Las Vegas, NV, USA

Methods:

Literature review using the following key words in Pub Med search: Trabeculectomy, Tube Shunts, Mitomycin C, 5-Fluorouracil, anti-inflammatory agents, anti-VEGF agents.

Results:

The literature indicates that there is no one clear therapy that predictably causes anti-scarring of glaucoma surgery. Most therapies are also off label. For the past several years Mitomycin C and 5-Fluorouracil have been the main therapeutic agents used in topical applications. Anti-VEGF agents have been emerging as a new class of adjuncts in filtering surgeries with measured success.

Conclusions:

The success (or failure) of glaucoma surgery depends on several factors, patient, previous surgeries, use of peri-operative drops and anti-scarring agents. Optimizing appropriate application of anti-fibrotic agents can influence the successful outcome of glaucoma surgery.

Financial Disclosure:

NONE