Evaluation of in vitro glistening formation in different hydrophobic acrylic intraocular lenses

Session Details

Session Title: Presented Poster Session: Cataract Surgery Outcomes

Session Date/Time: Tuesday 08/09/2015 | 09:30-11:10

Paper Time: 09:30

Venue: Poster Village: Pod 1

First Author: : G.Auffarth GERMANY

Co Author(s): :    R. Khoramnia   S. Liebing   F. Kretz   T. Tandogan     

Abstract Details

Purpose:

To compare the glistening formation in different hydrophobic acrylic intraocular lenses (IOLs) of different manufacturers.

Setting:

The David J. Apple International Laboratory for Ocular Pathology, Dept. of Ophthalmology, University of Heidelberg, Germany

Methods:

Four hydrophobic IOL models (AU6KA [Kowa, Japan], Envista [Bausch&Lomb, USA], Acrysof MA60AC [Alcon, USA], I-Sert PC-60AD [Hoya, Japan]) were analyzed. Glistenings were in an experimental setup created as aqueous-filled microvacuoles in five IOLs per model using an accelerated laboratory method. The IOLs were immersed in water at 45°C for 24 hours and then placed in a water bath with a temperature of 37°C for 2.5 hours to reduce the temperature. Images of the IOLs were taken with a camera attached to a microscope. The images were analyzed with an image analysis program (i-Solution) for the comparison of glistening formation.

Results:

Glistenings were detectable in all lenses after the accelerated laboratory method. The range of the microvacuole density for the IOLs was as follows (in microvacuoles per square millimeter [MVs/mm²]): 1-2 (Envista [Bausch&Lomb, USA]), 1-4 (AU6KA [Kowa, Japan]), 507-804 (Acrysof MA60AC [Alcon, USA]), 684-2699 (I-Sert PC-60AD [Hoya, Japan]).

Conclusions:

The amount of glistenings differed significantly between the examined IOLs. While two IOL models (AU6KA and Envista) only showed a glistening grade of 0 according to Miyata et al., the other two models (MA60AC and PC-60AD) showed a glistening grade of 3.

Financial Interest:

One of the authors receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented, One of the authors travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, One of the authors research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented