Comparison of mitomycin C 0,02% and 0,002% efficacy in preventing haze after photorefractive keratectomy

Session Details

Session Title: Photoablation Outcomes II

Session Date/Time: Wednesday 09/09/2015 | 08:00-09:30

Paper Time: 08:18

Venue: Room 1

First Author: : L.Coelho BRAZIL

Co Author(s): :    R. Sieiro   J. Lyra                 

Abstract Details

Purpose:

Purpose: to compare Mitomycin C (MMC) 0,002% efficacy in preventing haze after photorefractive keratectomy (PRK) in relation to MMC 0,02% usually employed.

Setting:

Laser Visão Clinic ,Belo Horizonte ,Minas Gerais, Brazil

Methods:

We conducted a prospective study with patients undergoing PRK by the same surgeon, the same surgical technique and the same excimer laser device. After PRK, patients received an application of MMC for 30 seconds at a concentration of 0,02% in the right eye (RE) and 0,002% on the left eye (LE). We assessed age, gender, spherical equivalent and haze intensity after one, 3, 6 and 12 months. Haze was evaluated at biomicroscopy by the same observer and quantified in 0 to 4+. Data were analyzed and p < 0,05 was considered statistical significant.

Results:

We evaluated 130 patients, 77 women and 53 men, with a mean age of 30,2  9 years old. The spherical equivalent was -3,66 D in RE and -3,77 D on LE (p = 0,04). In the first month after PRK, more than 80% of patients did not present haze. In the third month, there was an increasing in 0 to 2+/4+ of haze that gradually reduced in the next months. There was no correlationship between haze and age or gender or spherical equivalent. There was no difference in haze between RE and LE.

Conclusions:

MMC concentration was not significant in haze variation, whereas time was considered significant for its variation (p <0,05). MMC 0,002% was so effective as MMC 0,02% in prevention of haze after PRK. As there continue to be concerns regarding MMC long-term safety, we suggest the use of lower MMC concentration, in order to prevent long-term complications.

Financial Interest:

NONE