Visual acuity in endothelial keratoplasty (DSAEK) in infected primary grafts compared to non-infected primary grafts in a one-year follow-up study

Session Details

Session Title: Cornea: Surgical I

Session Date/Time: Tuesday 08/09/2015 | 08:00-10:30

Paper Time: 10:12

Venue: Room 10

First Author: : A.Hajjar Sese SPAIN

Co Author(s): :    N. Jacobsen   K. Holmgaard   J. Lindegaard   K. Hojgaard-Olsen           

Abstract Details

Purpose:

Evaluation of Visual Acuity (VA) in patients that underwent Descemet´s Stripping Automated Keratoplasty (DSAEK) with Infected Primary Grafts compared to patients that underwent DSAEK with non-infected grafts, in a period of one-year follow-up after surgery.

Setting:

The Eye Clinic at Copenhaguen University Hospital, that includes Rigshospitalet and Glostrup Hospital, Denmark.

Methods:

Retrospective study of a group of patients (n=8) undergoing DSAEK in the period between January 2013 and March 2014 were identified as primary infected grafts after positive microbial cultures of donor corneal buttons for isolation of fungi and bacteria. Visual outcomes one-year postoperative were compared to a similar group of patients (n=66) undergoing DSAEK in the period between July 2012 and January 2013. Individuals suffering form severe AMD, glaucoma, retinal detachment and congenital eye diseases were excluded (n=12) leaving a group of 54 patients. Type of microorganisms were stated and whether the infected grafts were explanted for re-DSAEK.

Results:

Gain in VA in primary infected grafts was 0,15 ± 0,08 (mean ± SEM) and 0,30 ± 0,03 (mean ± SEM) in non-infected primary grafts. There was not statistically significant difference between the two gains in VA (P=0.49, unpaired t-test). The microorganisms with positive cultures in grafts were fungi (n=4) and bacteria (n=3). 5/8 patients required explantation of infected grafts and re-DSAEK

Conclusions:

Gain in VA one-year postoperative in infected primary grafts versus non-infected primary grafts in DSAEK had not statistically significant difference. Nevertheless, there was a tendency towards a lower gain of VA in infected primary grafts.

Financial Interest:

NONE