NSAIDS vs steroids vs combination therapy in the prophylaxis of postoperative cystoids macular oedema

Session Details

Session Title: PCO. Cataract Surgery Complications/Management

Session Date/Time: Tuesday 08/09/2015 | 08:00-10:30

Paper Time: 09:48

Venue: Room 1

First Author: : Y.Abubakr EGYPT

Co Author(s): :    A. Salah   E. Aboubakr El Siddek Ahmed                 

Abstract Details

Purpose:

To evaluate the safety and efficacy of using topical keratolac 0.4% drops vs topical prednisolone vs a combination therapy of both drugs in the prevention and management of acute pseudophakic cystoid macular oedema (CME).

Setting:

Ophthalmology Department, Egypt Air Hospital, Cairo,Egypt.

Methods:

Randomized prospective non masked open label trial including 120 patients randomly distributed into 3 groups, the first group received topical keratolac 0.4% ,the second received prednisolone acetate 1% suspension drops, the third group received a combination therapy of both drugs. Treatments were continued for 4 weeks postoperatively. Patients' assessment included Snellen visual acuity, IOP, OCT scanning of the macula at day 1 and 4,8,12 weeks.

Results:

Results showed that 57.5% of the Prdnisolone 1% montherapy group developed CME and increase in CMT at 1 month duration(P=.035) compared to 17,5% of the keratolac 0.4% group and 2.5% of the combined therapy group.(P=.001).

Conclusions:

Combined topical NSAID and steroids showed superior efficacy in the prophylaxis and management of pseudophakic macular oedema compared to either drug monotherapy.

Financial Interest:

NONE