New approaches to optimising photorefractive ablation of the cornea

Session Details

Session Title: Photoablation Outcomes I

Session Date/Time: Monday 07/09/2015 | 16:30-18:30

Paper Time: 17:51

Venue: Room 17

First Author: : I. Kornilovskiy RUSSIA

Co Author(s): :    A. Burtsev   A. Sultanova                 

Abstract Details

Purpose:

To consider new approaches to the optimization photorefractive ablation of the cornea

Setting:

Photorefractive ablation of the cornea is accompanied by the weakening of its biomechanical and photoprotective properties.

Methods:

The base of the work is the experimental and clinical investigations according to the peculiarities of interaction of ablations doses of excimer laser radiation with cornea. The changes of biomechanics and photoprotective corneal functions after optimization photorefractive ablation of the cornea were studied. Clinical inverstigations embraced more than 25-years observations of results of different excimer laser refractive operations including new approaches to the optimization photorefractive ablation of the cornea during last 3 years.

Results:

Experimental and clinical investigations allowed to offer some new approaches to the optimization of technology of excimer laser refractive ablation. These approaches include preliminary saturation of corneal stroma by riboflavin for screening of the second radiation in UV and visible ranges which takes place in all cases of refractive ablation. Decrease of biomechanical corneal properties weakening at the expense of laser-induced cross-linking. Use of the various methods of UV photoprotection in postoperative period. In saturated riboflavin corneas secondary radiation induced fluorescence cascade collagen proteins and cross-linking. Biomechanical corneas testing in the experiments in vitro showed a significant increase in tensile strength (p=0,001), maximum strength (p=0,005) and tensile modulus of elasticity (p=0,016) in comparison with the ablated corneas without riboflavin.

Conclusions:

Technology photorefractive ablation with the preliminary saturation of corneal stroma by riboflavin is accompanied by the effects of photoprotection and laser-induced cross-linking, that decreases the weakening of biomechanical and photoprotective properties of cornea.

Financial Interest:

NONE