Filamentary keratitis epidemiology and treatment regimen

Session Details

Session Title: Cornea - Medical

Session Date/Time: Monday 07/09/2015 | 08:00-10:30

Paper Time: 09:06

Venue: Room 17

First Author: : I.Pronkin RUSSIA

Co Author(s): :    D. Maychuk                    

Abstract Details

Purpose:

To analyze concomitant pathology contributing to filamentary keratitis and to evaluate effectiveness of different treatment regimens.

Setting:

Fyodorov Eye Microsurgery Complex, Moscow, Russia

Methods:

We examined 38 patients (76 eyes) with filamentary keratitis. All of them were consulted by co-specialists (internist, endocrinologist, reumatologist) with the object to reveal concomitant diseases. All patients were divided into 3 groups depending on treatment regimen. The treatment included keratoprotectors, artificial tears, reparative eyedrops and one of the following components: Vitabact (1st group), Dexamethasone (2nd group), Restasis (3rd group). Besides, in case of decompensated concomitant disease, patients were treated by appropriate specialist. Among investigative methods were: patients' questionnaire, biomicroscopy, 5-region corneal fluorescein staining scale, Shirmer test – 1, TBUT- test. Follow-up period was 6 months.

Results:

Among concomitant pathology we revealed: Thyroid gland disfunction (34,2 %), rheumatoid arthritis (21,1 %) and their combination (10,5 %), Sjögren's Syndrome (2,6 %); II type diabetes mellitus (7,9 %); Combination of diabetes and thyroid gland dysfunction (13,2 %) and neither endocrine nor rheumatoid diseases (10,5 %). Shirmer test – 1 results were variable and no appropriateness with treatment regimen was found. TBUT-test data before treatment were low (6-9 sec.) with an increase up to 9-11 sec. after the treatment.

Conclusions:

Dexamethasone as a component of combined therapy contributed to rapid filaments' resorbtion, Restasis – to fast effect and stable remission. 89.5 % of patients had endocrine pathology or rheumatoid diseases or their combination. With this in view, we may consider filamentary keratitis not as a form of severe dry eye syndrome, but as a separate dystrophic corneal disorder with dry eye as its symptom.

Financial Interest:

NONE