In vitro toxicity study and sterilization process of modified drug eluting intraocular lenses

Session Details

Session Title: Pseudophakic IOLs: Monofocal. Cataract Surgery Instrumentation

Session Date/Time: Saturday 05/09/2015 | 16:00-18:30

Paper Time: 18:12

Venue: Room 10

First Author: : L.Lamprogiannis GREECE

Co Author(s): :    A. Karamitsos   V. Karagkiozaki   S. Logothetidis   S. Dimitrakos   I. Tsinopoulos        

Abstract Details

Purpose:

To present the process of sterilization and the in vitro toxicity study of modified, dexamethasone-eluting intraocular lenses.

Setting:

Anterior Eye Department, 2nd University Ophthalmology Clinic, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece. Laboratory for Thin Films, Nanosystems and Nanometrology, Physics Department of Aristotle University of Thessaloniki, Greece.

Methods:

3-piece acrylic intraocular lenses were coated with a polymeric drug-eluting organic thin film. They were studied with the use of Scanning Elctron Microscopy. They underwent sterilization with the use of ultraviolet light and their toxicity was evaluated in vitro.

Results:

The lens-thin film system demonstrated satisfactory results in terms of toxicity and the sterilization process proved to be effective.

Conclusions:

Further studies are necessary to evaluate the in vivo effectiveness and safety of these modified IOLs.

Financial Interest:

NONE