Posters

Human papilloma virus infection does not predict response of ocular surface squamous neoplasia to interferon therapy

Poster Details

First Author: S. Palioura USA

Co Author(s):    A. Galor   A. Nanji   M. Joag   G. Nuovo   G. Wang   C. Karp

Abstract Details

Purpose:

To identify the frequency of human papilloma virus (HPV) in ocular surface squamous neoplasia (OSSN), and assess differences in clinical features and treatment response of HPV positive versus negative tumors.

Setting:

Tertiary ophthalmology referral center- Bascom Palmer Eye Institute, University of Miami

Methods:

Retrospective case series of twenty-seven patients with OSSN whose biopsy specimens were analyzed for the presence of HPV. Clinical features and response to interferon were analyzed by HPV status. Twenty-one of 27 tumors (78%) were HPV positive. HPV genotypes identified included HPV 16 in 10 (48%), HPV 31 in 5, HPV 33 in 1, HPV 35 in 2, HPV 51 in 2, and a novel HPV in 3 (total 23 as one tumor had 3 genotypes identified). Tumors found in the superior limbus were more likely to be HPV positive (48% vs 0%, P = 0.06) and showed a poor response to topical interferon. HPV 16 positive tumors were larger (68 mm2 vs 34 mm2, P = 0.08) and were more likely to have a papillomatous morphology (50% vs 12%, P = 0.07). HPV positive status was not associated with a response to interferon therapy.

Results:

OSSN lesions in the non-exposed superior limbus tend to be HPV positive. A positive response to interferon is independent of HPV status.

Conclusions:

FINANCIAL DISCLOUSRE: NONE