Posters

Predictive factors of keratoconus progression

Poster Details

First Author: A.Lopes PORTUGAL

Co Author(s):    C. Pedrosa   P. Pego   C. Vendrell   I. Prieto     

Abstract Details

Purpose:

To determine predictive factors of keratoconus progression in patients with keratoconus in our department.

Setting:

Ophthalmology Department, Fernando Fonseca Hospital, Lisbon, Portugal

Methods:

Retrospective study of 93 eyes of 53 patients with keratoconus followed in our department. Topographic parameters obtained by Pentacam® were analyzed. We studied the predictive factors for progression of keratoconus cases up to 2-3 stage, with at least two Pentacam® tests done within at least 1 year without surgery during this period (36 eyes, 27 patients). We divided these patients between group with and without progression and having as a criterion for progression the increase of at least 1.50D in the central keratometry. Statistical analysis was performed using the SPSSv22 software. Tests were considered significant at p=0.05 significance level.

Results:

Of the 53 patients, 52.8% were male, mean age 23.3 ± 5.97 years and bilateral keratoconus (76.9%). Of the 36 eyes within our study parameters only 16 progressed, being the only clinical and epidemiological statistically significant parameters the early age at the diagnosis (p=0.045) and the eye rubbing habit (p=0.046). In the evaluation of the progression of topographic parameters statistically significant differences were found in all parameters of the anterior keratometry (p<0.05), Kmax (p=0.001), anterior and posterior astigmatism (p=0.044; p=0.008), ISV (p=0.002), CKI (p=0.001) and Rmin (p=0.001).

Conclusions:

A better understanding of patients' characteristics and keratoconus topographic parameters allows a more effective intervention. Early age at diagnosis, eye rubbing habit, anterior keratometry, astigmatism, Kmax, ISV, CKI and Rmin are potential predictors of progression. FINANCIAL DISCLOUSRE: NONE