Effects of a Dorzolamide/Timolol fixed combination on diurnal intraocular pressure, heart rate, blood pressure and ocular perfusion pressure in normal-tension glaucoma

Session Details

Session Title: Special Cases
Session Date/Time: Friday 26/02/2016 | 08:30-10:00
Paper Time: 08:42
Venue: MC3 Room
First Author: : N.Lee SOUTH KOREA
Co Author(s): :                  

Abstract Details

Purpose:

To evaluate the effects of a dorzolamide-timolol fixed combination (DTFC) on intraocular pressure (IOP), heart rate (HR), blood pressure (BP), ocular perfusion pressure (OPP), and diastolic ocular perfusion pressure (DOPP) in patients with normal-tension glaucoma (NTG).

Setting:

Hospital based.

Methods:

A prospective, interventional, single-blind, single-center study was conducted. Patients with newly diagnosed NTG that had not been treated with a glaucoma medication in the most recent 4 weeks were analyzed. Patients were examined on day 1 (without medication) and week 4 (under medication). Baseline IOP, HR, systolic and diastolic BP, OPP, and DOPP were measured at 8:00 AM, 12:00 PM, and 4:00 PM. At week 4, IOP, HR, BP, OPP, and DOPP were measured at 10:00 AM and 8:00 PM as well.

Results:

After 4 weeks of DTFC treatment, IOP was significantly reduced at all time points (1.6 - 2.6 mmHg, P < 0.001), and the average IOP reduction was 14.4%. HR and systolic BP showed no statistically significant difference at all time points; however, diastolic BP was decreased significantly at 12:00 PM and 4:00 PM (P = 0.004 and 0.001). Diurnal OPP increased with statistical significance after DTFC (P = 0.043). Diurnal DOPP showed no statistically significant difference after DTFC.

Conclusions:

DTFC has favorable effects on IOP and OPP and can be used without concerns of DOPP in patients with NTG.

Financial Disclosure:

NONE