Posters

Evaluation of biocompatibility of a new foldable intraocular lens made of a novel biomaterial of cross-linked polyisobutylene (xPIB) in a rabbit model

Poster Details

First Author: Z.Yun-e CHINA

Co Author(s):    C. Pingjun   Z. Yinying   P. Leonard              

Abstract Details

Purpose:

To assess biocompatibility of a new foldable intraocular lens (IOL) made of a novel biomaterial, crosslinked polyisbutylene (xPIB) in an in-vivo and histopathological study using a rabbit model

Setting:

1.The Eye Hospital of Wenzhou Medical University, Hangzhou, China 2. University of Miami, Miami, Florida, USA

Methods:

Twenty eyes from 20 New Zealand White rabbits were randomly operated on with phacoemulsification and implantation of 2 single-piece foldable IOLs of similar design features but different materials: 1) a hydrophobic crosslinked polyisobutylene material (PillarBio EyeDeal301, n=10) as a test article, and 2) a hydrophobic acrylic material (Alcon AcrySof SA60AT, n=10) as a control. Animals were observed for 6 weeks post-implantation. Responses from conjunctiva, cornea, AC, iris, were documented at day 1, 7, 14, 28, and 42. ACO, PCO and Soemmering’s ring (SR) formation were also observed. At the end of 6 weeks, all enucleated globes were assessed histopathologically.

Results:

Surgery-related inflammatory reaction of conjunctiva, cornea, AC and iris were observed in both groups in 2 weeks post-implantation. This inflammation reduced to none by week 6. There was no statistically significant difference between the two groups on inflammatory indicator scores. ACO, PCO, and SR formation were observed in both groups after 2 weeks post-implantation. ACO scores remained no significant change of accumulating scores, PCO and SR were on an exacerbating trend throughout the course of the study. There was no statistically significant difference between the two groups on secondary cataract indicator scores. Histopahtological findings were consistent with slit lamp findings.

Conclusions:

IOLs made of novel crosslinked polyisobutylene material demonstrated equally excellent biocompatibility when compared with Acrysof SA60AT IOLs in a rabbit model. The secondary cataract indicators also showed comparable outcome between the two groups.

Financial Disclosure:

None