Posters

Dynamic thiol disulphide homeostasi̇s in pati̇ents with surfer’s eye

Poster Details

First Author: H.Akcam TURKEY

Co Author(s):    O. Erel                    

Abstract Details

Purpose:

To investigate dynamic thiol-disulphide homeostasis in patients with conjunctival pterygium with a novel and automated method.

Setting:

Department of Ophthalmology, Duzce University School of Medicine, Düzce, Turkey and Department of Biochemistry, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

Methods:

Thirty-eight patients with pterygium (pterygium group, PG) and 35 age-sex matched healthy volunteers (control group, CG) were included in the study. Patients with acute-chronic ocular or systemic diseases other than pterygium, acute-chronic infection, systemic-ocular medication, smoking, alcohol use and pregnant women were excluded from the study. Native thiol, total thiol, disulfide levels were determined in blood samples of all cases. Disulfide / native thiol, disulfide / total thiol, native thiol / total thiol ratios were calculated.

Results:

Although the median native thiol was slightly lower in PG (318.2 µmol /L) compared to CG (333.4 µmol /L) and the mean disulfide was slightly increased in PG (24.3 µmol /L) compared to CG (22.8 µmol /L), this differences were not statistically significant While disulfide / native thiol and disulfide / total thiol ratio were shifted in favor of PG, native thiol / total thiol ratio was shifted in favor of CG. But these difference did also not reach statistical significance level. Correlation test suggested negative correlation between native thiol and total thiol levels and grade of pterygium in PG.

Conclusions:

There was a slight shift in thiol / disulfide homeostasis in the favor of oxidation in patient with pterygium which is considered to be a local ocular disease. The investigation of this probable relationship with larger studies may raise atioxidant therapies in these cases.

Financial Disclosure:

None