Posters

Corneal properties in primary open angle glaucoma: topgraphic and densitometric evaluation with scheimpflug

Poster Details

First Author: M.Molero Senosiain SPAIN

Co Author(s):    L. Morales Fernandez   L. Perucho Gonzalez   J. Garcia Bella   F. Saenz Frances   J. Garcia Feijoo   J. Martinez De La Casa     

Abstract Details

Purpose:

To measure corneal topography and densitometry in patients with primary open angle glaucoma in different stages (early, moderated and advanced) and compare it with healthy subjects.

Setting:

Corneal densitometry the measures were taken from the 12mm diameter area of the cornea divided in 4 concentric radial zones (from 0-2mm, 2-6mm, 6-10mm and 10-12mm) and also subdivided in depth layers (anterior, central and posterior).

Methods:

Corneal topography using Pentacam HR was carried out in 200eyes from 200caucasian people, 75patients with primary open angle glaucoma (POAG) divided in grades of severity and 125healthy subjects. For the analysis several variables were compared: sex, age, intraocular pressure(IOP), keratometry(Kminimum, Kmaximum and Kmean), cylinder, central corneal thickness(CCT). Other parameters evaluated were also central anterior elevation(CAE), anterior elevation apex(AEA), maximum anterior elevation(MAE) and posterior elevation apex(PEA).Data were compared by determining interclass correlation coefficient for each corneal parameter and IOP. The receiver operator characteristic(ROC) was used to determine the diagnostic capacity of the variables using the area under curve(AUC) and Youden Index.

Results:

Mean age in control group was 64.16 ± 1.34 years and 72.20 ± 1.38 years in POAG group. In control group 35.2% were male and 42.66% in POAG group. Both groups were comparable in age (p=0.063), sex (p=0.29) and examined eye (p=0.1). There were statiscally significant differences among topographic characteristics CAE (p=0.004) and PEA (p=0.042). Regarding to anterior chamber parameters only the anterior chamber angle (ACA) was higher in POAG (p=0.006). There were also differences in corneal densitometry between controls and POAG, being higher in POAG in almost all rings and layers statistically significant: anterior, mid stroma and total thickness and also in the full thickness total area. There were no differences statistically significant in the posterior layer, except in 2-6 mm ring (p=0.034). There was not found correlation between corneal densitometry and mean defect in different severity groups of glaucoma. There were also no differences statistically significant between corneal densitometry and queratometry (p>0.01). It was found a positive correlation between total corneal densitometry and age (r=0.623; p<0.001). It was shown the diagnostic capacity of full thickness total area (0.617) con IC 95% [0,541-0,697] and p<0.001.

Conclusions:

Our results have shown that corneal densitometry is different in healthy subjects and patients with POAG and it seems that corneal properties are different between them. In addition, considering the diagnostic capacity of corneal densitometry, this measurement could be incorporated into the usual practice for its role in the diagnostic and prognostic support of glaucoma. New studies are needed to determine if the alteration of the corneal characteristics, including densitometry, is a primary or secondary alteration in patients with POAG.

Financial Disclosure:

None