Posters

Correlation between inflammatory profile in aqueous humor in patients who underwent femtosecond laser-assisted cataract surgery and cataract degree

Poster Details

First Author: M.Roig Revert SPAIN

Co Author(s):    C. Peris Martínez   G. Rodríguez Iranzo   M. Cerdá Ibañez   S. Montolío Marzo   M. Hernández   E. FernáNdez López     

Abstract Details

Purpose:

Cataract surgery is one of the most usual type of intervention worlwide. Thanks to the improvement of technology and investigation this kind of surgery has reached a very high success rate. Studies have compared femtosecond laser-assisted versus traditional phacoemulsification cataract surgery in terms of inflammation, but there are also other variables which can influence the final result, such as cataract degree. The purpose of this study is to establish the influence of cataract degree in the inflammatory profile of the aqueous humor in patients who underwent femtosecond laser-assisted cataract surgery (FLACS).

Setting:

Cornea and Anterior Segment Department, FISABIO Oftalmologia Medica (FOM), Valencia, Spain.

Methods:

Prospective, consecutive case series study in patients who underwent FLACS surgery in our center. In the firt visit we classified the cataract degree with the Lens Opacities Classification System (LOCSIII) and we established 2 groups: mild cataract group (grade≤3) and advanced catarat group (grade≤4). Clear corneal incisions, capsulorhexis and lens fragmentation was performed with femtosecond laser. After this, we collected samples of aqueous humor and we continued with the phacoemulsification and intraocular lens implantation in the bag.The parameters determined in aqueous humor were interleukins IL6 and IL8, and tumor necrosis factor α (TNF- α) which were analyzed through ELISA assays.

Results:

We included 75 patients (58,7% of women and 41.3% of men). Mean age was 73,51± 8,5 years. We obtained 75 samples of aqueous humor. Mean concentrations of IL-6 and IL-8 in mild cataract group were 3.18267pg/ml and 1.54pg/ml respectively; in advanced catarat group were 8.11174 pg/ml and 1.84 pg/ml respectively, however no significative differences were found (p=0.08 for IL-6; p=0.23 for IL-8). Mean concentrations of TNF-α were 0.463pg/ml in mild cataract group and 0.268pg/ml in advanced catarat group, but no significative differences were found neither.

Conclusions:

No significative differences were noticed between the two groups and their inflammatory reaction to the surgery. Although there was a slight tendency in IL6 and IL8 to increase their concentrations in advanced cataracts, a sign that could mean that the cataract itself can modulate ocular inflammation. On the other hand, the opposite happened with the concentration of TNFα that diminished in advanced cataracts, which may be due to a physiological attempt to restore basal cytokine levels in aqueous humor.

Financial Disclosure:

None