Posters

Correlation between inflammatory profile in aqueous humor in patients who underwent femtosecond laser-assisted cataract surgery and diabetes mellitus

Poster Details

First Author: G.Rodriguez Iranzo SPAIN

Co Author(s):    C. Peris Martínez   M. Roig Revert   M. Cerdà Ibañez   S. Montolío Marzo   M. Hernández   E. Fernández López     

Abstract Details

Purpose:

Cataract surgery is one of the most usual type of intervention worldwide. Thanks to the improvement of technology and investigation this kind of surgery has reached a very high success rate. Studies have compared femtosecond laser-assisted versus traditional phacoemulsification cataract surgery in terms of inflammation, but there are also other variables which can influence the final result, such as diabetes. The purpose of this study is to establish the influence of diabetes in the inflammatory profile of the aqueous humor in patients who underwent femtosecond laser-assisted cataract surgery (FLACS).

Setting:

Cornea and Anterior Segment Department, FISABIO Oftalmologia Medica (FOM), Valencia, Spain.

Methods:

Prospective, consecutive case series study in patients who underwent FLACS surgery in our center. We classified the patients in three groups: Non diabetic, non insulin-dependent and insulin-dependent diabetic patients. Clear corneal incisions, capsulorhexis and lens fragmentation was performed with femtosecond laser. We collected samples of aqueous humor and continued with the phacoemulsification and intraocular lens implantation. The parameters determined in aqueous humor were interleukins IL6 and IL8, analyzed through ELISA assays. Once this classification and surgery was made, the non-parametric statistics of the median, Kruskal-Wallis test were calculated to verify whether diabetes influenced the inflammatory profile of aqueous humor.

Results:

We included 75 patients (58,7% of women and 41.3% of men). Mean age was 73,51± 8,5 years. We obtained 75 samples of aqueous humor. Mean concentrations of IL-6 were 3.064 pg/ml in non diabetic (54 samples), 4.414 pg/ml in non insulin-dependent (15 samples) and 111.313 in insulin-dependent diabetic patients (6 samples), much higher than in the first two groups, with significative differences found (p=0.034). As for the IL-8, there are also variations in the concentrations for the three groups (p=0.012). Mean concentrations of IL-8 were 1.544 in non diabetic, 1.487 in non insulin-dependent and 5.298 in insulin-dependent diabetic patients.

Conclusions:

Significative differences were noticed between the three groups and their inflammatory reaction to the surgery. There was a tendency in IL6 and IL8 to increase their concentrations in diabetic patients, above all in those with insulin-dependent diabetes, a sign that could mean that the diabetes itself can modulate ocular inflammation. It must be noticed that the group of diabetic patients for this study has been quite reduced (Non insulin-dependent diabetes N=15, Insulin-dependent diabetes N=6), so more complete studies are required to verify these results.

Financial Disclosure:

None