Posters

Evaluation of specular microscopy, corneal densitometry and meibography in patients with acne rosacea patients

Poster Details

First Author: D.Ozek TURKEY

Co Author(s):    D. Ozek   E. Karaca   O. Kemer              

Abstract Details

Purpose:

To evaluate endothelial layer, corneal densitometry and meibography of patients with acne rosacea.

Setting:

Ankara City Hospital Opthalmology Department, Turkey

Methods:

Fourty eyes of 40 patients with acne rosacea who were newly diagnosed (group 1) and 40 eyes of 40 healthy individuals (group 2) were enrolled. Corneal densitometry of all subjects were evaluated by Scheimpflug topography (Pentacam, Germany). Cell density, cell distribution, cell morphology of the endothelial layer were examined in both groups using specular microscopy (Nidek CEM 530, USA). The first and average non-invasive tear break up time (f-NTBUT, a-NTBUT) and upper and lower meibomian gland area of loss percentages (MGALP) and meiboscores were assessed using meibography (Sirius, CSO, Italy). Oxford scoring, ocular surface disease index score (OSDI) were evaluated.

Results:

The mean ages of group 1 (29 female, 11 male) and group 2 (26 female, 14 male) were 39.51±8.3, and 41.49±.1 years respectively (p= 0.225). Group 1 consisted of 26 papulopustular,12 erythematotelangiectatic, 2 phymatous patients. OSDI, Oxford scores, meiboscores and MGALP upper and lower eyelids, anterior 0-2 mm and 2-6mm corneal densitometry were significantly higher in group 1 than in group 2 (p = 0.04, p= 0.00, p=0.00, p= 0.04, p=0.00, p=0.03 respectively) whereas f-NTBUT and a-NTBUT were significantly lower in group 1 than in group 2 (p=0.01, p=0.01 respectively). There was no significant difference between the groups in terms of cell density, cell distribution and cell morphology in specular microscopy (p> 0.05).

Conclusions:

Acne rosacea causes significant meibomian gland loss and corneal densitometry changing in 0-6 mm annular zone of anterior region that can objectively be demonstrated with meibography and corneal densitometry assessment. Acne rosacea can cause dry eye associated with dropout in meibomian glands and this effect may cause increasing in the anterior corneal densitometry.

Financial Disclosure:

None