Posters

Evaluation of inflammatory biomarkers in patients with keratoconus

Poster Details

First Author: R.Oltulu TURKEY

Co Author(s):    A. Gundogan   Z. Katipoglu   E. Mirza   S. Belviranli           

Abstract Details

Purpose:

To investigate the monocyte-to-HDL-cholesterol ratio (MHR), neutrophil to lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocytes ratio (ELR), platelet distribution width (PDW), red blood cell distribution width (RDW), mean platelet volume (MPV), MPV to platelet count ratio (MPV/PC) and RDW to platelet ratio (RPR) that are accepted as inflammatory markers in patients with keratoconus.

Setting:

Meram Faculty of Medicine, Necmettin Erbakan University, Konya/Turkey

Methods:

In this study, 43 patients with keratoconus and 43 healthy individuals as the control group were retrospectively evaluated. Lymphocyte, neutrophil, eosinophil, monocyte, platelet, MPV, PDW, and RDW values were obtained with complete blood count performed on the peripheral blood samples.

Results:

Absolute monocyte (593±182 vs 492±177; p <0.05) and neutrophil (4860±1553 vs 3954±1297; p <0.05) counts were statistically significantly higher in the keratoconus groups compared to the control groups. MHR (13.18±5.02 vs 9.88±4.45; p <0.05) and NLR (2.30±0.87 vs 1.77±0.61; p <0.05) were statistically significantly higher in the keratoconus group. As a result of univariate logistic regression analysis, it was observed that MHR and NLR, which are among the laboratory parameters, were statistically determinant in predicting the presence of keratoconus (p=0.020 and p=0.021). [Odds ratio=5.41 (95%CI: 1.169-6.669) and Odds ratio:5.28 (95% CI: 1.024-1.321); respectively]. LMR was statistically significantly lower in the keratoconus group (p <0.05). Adjusting for age and gender, multivariate regression analysis revealed that MHR was the most significant parameters for predicting of the disease (p=0.025) [Odds oranı=4.99 (95% CI: 1.019-1.332)].

Conclusions:

MHR and NLR values were statistically higher while LMR was lower in the keratoconus patient group.

Financial Disclosure:

None