Posters

Histopathological study of conjunctival tissue after plasma treatment

Poster Details

First Author: F.Nejat IRAN

Co Author(s):    K. Jadidi   H. Aghamollaei   S. Adnani   B. Nejat           

Abstract Details

Purpose:

Plasma offers an alternative to invasive surgical cosmetic procedures, reducing recovery time and any complications that can arise before and after surgery. Based on this topic, for the first time we evaluated the safety of the plasma on the conjunctiva tissue in animal model.

Setting:

Vision Health research Center, Semnan University of Medical Sciences, Semnan, Iran

Methods:

fifteen adult male New Zealand albino rabbits which divided into five groups were used. Experiments were performed on conjunctiva under the influence of created plasma by the Plexr device. Four spots were created on the conjunctiva using white hand piece of Plexr. For evaluation of plasma safety, ocular surface integrity and histopathological changes were assessed after 48 h (A), one week (B), one (C), three (D) and six (E) months after intervention.

Results:

After 48 h of plasma administration subconjunctival and conjunctival stromal edema and decreased blood vessels is noted .Epithelium reveals focally loss and marked thinning. After one week, all specimen show conjunctival stromal edema but less than group (A) without any congestion and hemorrhage. Epithelium show mild repair. Decreased blood vessels in the stroma is also noted. Generally, after one month loss of integrity of corneal epithelium has been completely improved. There is no evidence of malignancy in conjunctiva after 3 and 6 months.

Conclusions:

Our results showed the safety of Plasma on the conjunctiva in animal model. Plasma may be an alternative method for treatment of some ocular surface disorders. For more reliable results, a pilot clinical trial in human is proposed.

Financial Disclosure:

None