Posters

A rare ocular graft-versus-host disease in an allogeneic hematopoieti stem cell transplantation: case report

Poster Details

First Author: A.Cunha PORTUGAL

Co Author(s):    J. Pinheiro-Costa   R. Moreira   F. Falcão-Reis              

Abstract Details

Purpose:

To describe a rare ocular Graft-versus-Host disease in an allogeneic hematopoieti stem cell transplantation

Setting:

Department of Ophthalmology, Centro Hospitalar de São João Hospital, Porto, Portugal

Methods:

Clinical and imaging description of a clinical case.

Results:

A 54 years old male patient previous diagnosed with acute myeloid leukemia and underwent allogeneic stem cell transplantation. After transplantation, he developed chronic graft-versus-host disease, currently treated with oral ciclosporin. He complained bilateral foreign body sensation. Biomicroscopy revealed advanced ocular chronic GvHD and KCS grade V of the Oxford Scheme scale in the right eye and descemetocele which evolved to perforation days after in the left eye (LE). Penetrating keratoplasty 8.00/8.25 mm (cornea melting area) was performed. Two weeks after, due to persistente epitelial defect, amniotic membrane was applied. An intensive topical treatment with lubricants, autologous serum eye drops, fluromethalone, cyclosporine and ofloxacin was performed. Five months later, biomicroscopy revealed in a KCS grade IV of the Oxford Scheme scale in both eyes and in the LE without signs of infection or graft rejection and the epithelial defect healed.

Conclusions:

Our main treatment goal was to stabilize the ocular integrity. In our case, penetrating keratoplasty and amniotic membrane transplantation was performed in the left eye, but further topical treatment with autologous serum eye drops, preservative-free artificial tears and topical anti-inflammatory stabilized the ocular surface.

Financial Disclosure:

None