Posters
Pure corneal epithelium intraepithelial neoplasia: a case report
Poster Details
First Author: A.Campos SPAIN
Co Author(s): P. Alvarez Fernández I. Pereira Gonzalez A. De la Fuente Campos
Abstract Details
Purpose:
Pure intraepithelial neoplasia of de corneal epithelium without apparent macroscopic limbal-conjuntival involvement is a rare entity that could represent a challenge in the diagnosis and treatment of the condition. Few diagnostic clues such as biomicroscopy (BMC), confocal microscopy and anterior segment OCT can be helpful in de diagnosis.
Setting:
Ophthalmology Department, Jerez de la Frontera University Hospital, University of Cádiz, Spain.
Methods:
One patient, one eye complaining of blurred vision following uneventful cataract surgery. BMC showed hazy epithelium with fine punctate epithelial staining throughout the whole cornea, and minute limbal vessels invading de peripheral cornea but with the absence of de typical pinky, fleshy vascularized limbo-conjunctival lesion. Anterior segment OCT, Confocal microscopy and biomicroscopy were the clues to reach the diagnosis due to the unavailability of impression citology.
Interferon Alpha 2 Beta 1 million UI/ml eye drops four times a day was used to treat the tumour until the important reduction of the lesion will allow to be removed by scraping it.
Results:
The lesion was diminished after a year following the treatment with Interferon eye drops; however, it will need the removal of isolated remnants of abnormal tissue by scraping and soaking the lesion with alcohol 20%.
Conclusions:
1. Pure intraepithelial neoplasia of the corneal epithelium is a challenging pathology and it has to be kept in mind when making a differential diagnosis for epithelial haziness and punctate keratopathy.
2. BMC, anterior segment OCT and confocal microscopy findings are clues in the diagnosis.
3. Interferon alpha2 beta 1 million UI/ml eye drops is effective treatment to resolve or reduce the size this corneal tumour.
Financial Disclosure:
None
