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Two-year results of allogenic corneal lenticule of hyperopic SMILE for post-LASIK ectasia

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First Author: M.Li CHINA

Co Author(s):    X. Zhou                    

Abstract Details

Purpose:

To investigate the safety, efficacy, and corneal changes following allogeneic lenticule implantation for post-LASIK corneal ectasia.

Setting:

Department of Ophthalmology, EYE & ENT Hospital of Fudan University, Shanghai, China

Methods:

In this prospective, interventional case series, seven eyes from seven patients (five males, two females) with post-LASIK ectasia presenting during the period between 2015 and 2018 were included in this study. For the recipient eyes, flaps were opened and lifted. Lenticules with a mean cryopreserved time of 20±21 days extracted from the SMILE donor were transferred on to the exposed stromal bed and the flap was repositioned.Patients were followed up for a period of 2 years. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, manifest refraction, corneal topography, optical coherence tomography (OCT), and in vivo confocal microscopy were performed.

Results:

On the last visit, the safety and efficacy indices were 1.49±0.39 and 0.74±0.59, respectively. UDVA improved from 1.59±0.41 preoperatively to 0.79±0.35 (LogMAR). Two eyes (29%) gained one line of CDVA, three (43%) gained two lines, and one (14%) gained three lines. No eyes lost more than two lines. Spherical equivalents decreased from -11.95±5.91 D to -7.46±4.79 D (P=0.029). Anterior K of six eyes (85.7%) decreased greater than 1.0 D. Mean anterior K values changed from 53.91±7.80D to 51.11±8.51D (P=0.005). The smallest corneal thickness increased from 353.1±48.7μm to 405.1±56.5 μm(P=0.0008).

Conclusions:

Results of this study indicate that implantation of a concave allogenic lenticule may provide an alternative in the treatment of post-LASIK ectasia, although its refractive predictability remains to be further refined.

Financial Disclosure:

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