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Biocompatibility of acrylic intraocular lenses in eyes with pseudoexfoliation syndrome: Aspira-aA (HumanOpticsAG) vs AcrySof SA60AT (Alcon Lab) – one year follow-up

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First Author: A.Rozegnal-Madej POLAND

Co Author(s):    A. Rozegnał-Madej   T. Żarnowski                 

Abstract Details

Purpose:

To compare uveal and capsular biocompatibility of hydrophilic acrylic Aspira-aA and hydrophobic acrylic AcrySof SA60AT intraocular lenses in eyes with pseudoexfoliation syndrome (PEX).

Setting:

Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland

Methods:

In this prospective study, 226 eyes of 207 patients with senile cataract (115 eyes with PEX, 111 non-PEX (N)) were enrolled. Patients were divided into four groups: Aspira-PEX (n=76 eyes; mean age=78.7 ± 0.81 years), Aspira-N (n=73 eyes; mean age=73.7 ± 1.08 years), SA60AT-PEX (n=39 eyes; mean age=76.5 ± 1.22 years) and SA60AT-N (n=38 eyes; mean age=72.9±1.52 years). Eyes were examined 7 days, 3 months and 1 year after surgery. The amount of central and peripheral PCO (score 0-4), rhexis edge and entire capsule ACO (score 0-3), LEC outgrow (score 0-3) and laser flare tyndalometry (FM-500, Kowa) were assessed.

Results:

One year postoperatively, the subjective central and peripheral PCO scores were not statistically different between all groups. Rhexis edge and entire capsule ACO scores were higher in PEX groupssimilar for both lenses. LEC ongrowth onto IOL anterior surface was almost only found in eyes with the AcrySoflens (Aspira-N: 0.10 ± 0.6 vsAcrySof-N: 1.2 ± 2.1 (p<0.0001); Aspira-PEX: 0.11 ± 0.5 vsAcrySof-PEX: 0.45 ± 0.9 (P<0.0066). Laser flare results were significantly lower in the Aspira-aA non-PEX eyes(Aspira-PEX:1.40±0.25; SA60AT-PEX 2.62 ± 0.27; Aspira-N 2.35 ± 0.29; SA60AT-N 2.85 ± 0.38).

Conclusions:

Evaluated acrylic IOLs - Aspira-aA and AcrySof SA60AT - have good biocompatibility both in eyes with and without pseudoexfoliation. In terms of uveal biocompatibility, the inflammatory reaction one year after surgery was smaller in the Aspira-aA groups, especially in eyes with PEX.In terms of capsular biocompatibility, PCO results after 1 year were low in all groups but ACO outcomes were higher in PEX eyes in both IOL models. LEC outgrowth from the capsulorhexis towards the IOL anterior surface was almost exclusively found on AcrySof SA60AT IOLs, which show that LEC outgrowth is mainly material dependent.

Financial Disclosure:

... research is funded, fully or partially, by a competing company