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Evaluation of accommodation & OCT guided depth control after laser scleral microporation in presbyopic non human primate eyes

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First Author: J.Mehta SINGAPORE

Co Author(s):    A. Hipsley   Y. Liu   B. Hall              

Abstract Details

Purpose:

To evaluate and characterize treatment depth along with effects of Laser Scleral Microporation (LSM) using optical coherence tomography.

Setting:

Animal Study performed at the Singapore National Eye Centre, 11 Third Hospital Ave, Singapore 16875

Methods:

Six non-human primates (n = 12 eyes) at presbyopic age underwent LSM. The LSM treatment utilized a 2.94um Erbium Yttrium Aluminum Garnet (Er:YAG) laser in 4 oblique quadrants on the sclera to rejuvenate age-related ocular rigidity reduce biomechanical stiffness, and improve efficiency of the ciliary muscles in 5 critical zones of anatomical and functional significance. Slit lamp, optical coherence tomography (OCT), intraocular pressure (IOP) measurements, and accommodation were performed postoperatively. Wound healing profiles were also characterized at 1 and 3 months postoperatively and examined for stability.

Results:

Novel OCT guided depth control was utilized to control the depth of micropores in the non-human primate eyes. Target depth was achieved with accuracy and precision, and micropore depth was stable throughout the postoperative period. Preoperative IOP was reduced postoperatively in the non-human primate eyes. Effective range of focus, true accommodation, and pseudoaccommodation were all improved postoperatively. There was minimal scleral fibroblast migration into the micropores postoperatively.

Conclusions:

Novel OCT guided depth control is a useful tool to target the creation of scleral micropores at particular depths. LSM at approximately 80% depth of the sclera appears to not only improve accommodative ability, but also to reduce IOP. Wound healing profiles demonstrated in this study showed rejuvenated scleral tissue to remain stable over time.

Financial Disclosure:

... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented