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Four-year observation of the changes in corneal endothelium cell density and the correlated factors after Implantable Collamer Lens V4c implantation

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First Author: X.Zhou CHINA

Co Author(s):    W. Wen Yang   J. Zhao   L. Sun   L. Niu   X. Wang        

Abstract Details

Purpose:

To evaluate the changes in corneal endothelium cell density (ECD) and the correlated factors after Implantable Collamer Lens (ICL) V4c implantation.

Setting:

Department of Ophthalmology, Eye and ENT Hospital of Fudan University

Methods:

In this retrospective, consecutive study, 48 eyes of 25 patients with myopia who underwent ICL V4c implantation were enrolled. Patients were followed-up for at least 4 years, during which manifest refraction, uncorrected distance visual acuity, corrected distance visual acuity (CDVA), intraocular pressure, ECD, anterior chamber depth, anterior chamber volume (ACV), anterior chamber angle (ACA), vault, and distance from the corneal endothelium to the central ICL (C-ICL) were measured. Spearman’s correlation analysis was used to identify variables correlated with changes in ECD, and multiple stepwise regression analysis was used to predict changes in ECD.

Results:

All surgeries were performed safely with no complications during follow-up (average, 52±2.9 months; range, 48–57 months). Safety and efficacy indices were 1.23±0.22 and 1.04±0.16, respectively. No eyes had decreased CDVA, and 67% gained one or more lines. Further, 79% were within ±0.50 D, and 100% were within ±1.0 D of the attempted refraction. Additionally, a 4.03±2.2% reduction in ECD compared to the preoperative value was observed at the last follow-up visit. Changes in ECD significantly correlated with vault, C-ICL, change in ACA, and C-ICL. The vault was significantly associated with changes in ECD.

Conclusions:

ICL V4c implantation is safe and effective for myopia correction. Anterior segment biometric parameters including the vault, ACA, and C-ICL may influence changes in ECD; specifically, the vault plays a major role.

Financial Disclosure:

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