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Cationic nanoemulsion vs sodium hyaluronate eye drops after photorefractive keratectomy

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First Author: A.Cieślińska-Rypolc POLAND

Co Author(s):    K. Jadczyk-Sorek   I. Jaworowska-Cieślińska   B. Bubała-Stachowicz   B. Kałużny   E. Mrukwa-Kominek        

Abstract Details

Purpose:

To compare the influence of eye drops containing cationic nanoemulsion and sodium hyaluronate on early postoperative healing process in patients after photorefractive keratectomy (PRK).

Setting:

This multicenter, prospective, randomized, masked, parallel-group (1:1), comparative study included 128 patients (256 eyes) with myopia and myopic astigmatism in average age of 32,9 ±7,1 years who underwent photorefractive keratectomy.

Methods:

Group I used a multiple ingredient cationic nanoemulsion whereas group II used 0,15 % sodium hyaluronate, other postoperative topical medications remaining the same in both groups. Best uncorrected visual acuity (UCVA) and subjective patient’s experiences in Ocular Surface Disease Index (OSDI) were assessed using a questionnaire referring to the periods before, one week after and one month after the procedure. One week postoperatively, the completeness of corneal epithelization was also verified. Moreover, patients subjectively evaluated comfort of application, eye irritation and the extent of vision deterioration after instilling both types of eye drops.

Results:

One week after the surgery UCVA was 0.85±0.25 (decimal) in group I and 0.73±0.33 in group II, and one month after 0.92±0.22 and 0.82±0.26 respectively (p<0.01). In group I OSDI score after a week was 40.15±13.54 and in group II 44.27±12.59, whereas one month post-op it was 9.27±6.74 and 12.89±10.88 respectively (p<0.01). An incomplete epithelization after a week was less common in group I and subjective evaluation of cationic nanoemulsion was higher.

Conclusions:

Multiple ingredient lubricating eye drops with cationic nanoemulsion improves early postoperative healing process affecting visual acuity and comfort of patients after photorefractive keratectomy.

Financial Disclosure:

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