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Optical coherence tomography angiography: a new prognostic tool for penetrating keratoplasty?

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First Author: C.Khodriss MOROCCO

Co Author(s):    M. Mouajab   A. Bennis   F. Chraibi   M. Abdellaoui   I. Andaloussi Bentiya        

Abstract Details

Purpose:

Preoperative corneal neovascularization (NV) is thought to be associated with an increased rate of corneal graft failure and potentially also graft rejection. The aim of this study is to evaluate the value of optical coherence tomography angiography (OCTA) for diagnostic, measure and monitoring corneal NV.

Setting:

Ophtalmology department, Hassan II University Hospital Center (University of Sidi Mohammed Ben Abdellah).FEZ. Morocco.

Methods:

Corneal NV of varying severity, distribution, and underlying etiology was examined. Average NV depth and vessel density were measured using 1850 nm sweept source OCTA before and after Subconjunctival bevacizumab. The OCTA results were compared with slit-lamp estimation of NV. The statistical analysis were performed using SPSS V.20.

Results:

19 eyes with corneal NV of 19 patients undergoing to penetrating keratoplasty were included. The mean age was 46,11 years with 11 men and 8 women. viral keratitis was the main etiology of neo-vessels. All patients received at least one subconjunctival injection of bevacizumab with an average of 2.5. Analysis by OCT A showed superiority over biomicroscopic examination (p = 0.012) in the diagnosis and monitoring of corneal NV.

Conclusions:

Corneal OCT A was able to detect sublinical neovascularization, and provide an objective monitoring for new vessels treated with subconjunctival bevacizumab. These findings suggest possible applications of OCTA as a prognostic tool for penetrating keratoplasty.

Financial Disclosure:

... receives non-monetary benefits from a company producing, developing or supplying the product or procedure presented