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Three dimensional morphogeometric and volumetric characterization of the cornea in paediatric patients with early keratoconus

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First Author: I.Toprak SPAIN

Co Author(s):    F. Cavas   J. Velázquez   J. Alió del Barrio   J. Alió           

Abstract Details

Purpose:

To reveal morphogeometric and volumetric characteristics of the cornea and its diagnostic value in paediatric patients with early and mild keratoconus (KC) using three-dimensional (3D) corneal modeling.

Setting:

VISSUM Innovation, Alicante, Spain

Methods:

Forty-nine eyes of 49 paediatric patients (age ≤16 years) with KC and 31 eyes of 31 healthy paediatric controls were included into the study. Eyes were graded as early (n=21) and mild KC (n=28) based on the RETICS classification system. 3D corneal morphogeometric model was generated using raw topographic data. Following parameters were analyzed; deviation of anterior (Dapexant) and posterior (Dapexpost) apex, and minimum thickness points (Dmctant, Dmctpost), Dapexant-Dapexpost difference, total corneal volume (Vtotal), volumetric distribution (VOLPAP, VOLAAP and VOLMCT) and percentage of relative volume increase (VOLAAPrel, VOLPAPrel and VOLMCTrel) between two consecutive radii around anterior/posterior apices and MCT.

Results:

Dapexpost and Dapexant-Dapexpost difference (absolute) were significantly higher in the early and mild KC groups when compared to the control group (p<0.05). Eyes with early and mild KC had decreased Vtotal than in the control group (p<0.05). Dapexpost, Dapexant-Dapexpost difference and VOLMCTrel between 1.0 to 1.4 mm diameters had area under receiver operating characteristic curve (AUROC) values over 0.93 in discrimination of early KC from normal.

Conclusions:

Conclusions: This is the first study presenting morphogeometric and volumetric characterization of the cornea in paediatric patients with early and mild KC using a 3-D corneal model. Integration of the morphogeometric and volumetric characteristics to any topography software can add value in early diagnosis of KC in paediatric patients, which has critical importance.

Financial Disclosure:

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