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Two year outcome of topography-guided photorefractive keratectomy with collagen cross-linking for keratoconus

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First Author: M.Bizrah UK

Co Author(s):    D. Lin   S. Holland   F. Freiberg   S. Mosquera   S. Verma        

Abstract Details

Purpose:

To evaluate 24 months results of topography-guided Photorefractive Keratectomy (TG-PRK) with simultaneous collagen cross-linking (CXL) for keratoconus

Setting:

Laser Eye Centre

Methods:

Retrospective consecutive series of keratoconic eyes were studied to evaluate the outcomes of Topographic Guided Photorefractive Keratectomy (TG-PRK) with the Schwind Amaris 1050 Excimer laser with simultaneous corneal collagen cross-linking (CXL). Image capture with Sirius and CXL with the Athens protocol. Pre-operative and post-operative uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction (MR) and topographic data were analyzed. Cases with sufficient data at 24 months follow-up were included.

Results:

270 eyes had sufficient data at 24 months for analysis. 154 of 270 (57%) showed UDVA ≥20/40 post-operatively. 121 eyes (45%) had improved CDVA and 59 (22%) gained two or more lines while 61 eyes (23%) had loss CDVA with 29 (11%) lost 2 lines or more. Mean astigmatism was reduced from 3.24±1.70D to 1.86±1.65D (p ˂ 0.0001). Mean spherical equivalent was improved from -2.54±2.94D to -0.97±2.24D (p ˂ 0.0001). 4 eyes showed progression and 5 with haze judged sufficient to reduce CDVA.

Conclusions:

Two year results of topography-guided PRK (Schwind Amaris) treatment with CXL for keratoconus show efficacy and safety, with more than half achieving 20/40 UDVA or better. Almost half (45%) had improved CDVA and more than one fifth (22%) had CDVA improved two or more lines. It provides an alternative to contact lens intolerant keratoconus patients

Financial Disclosure:

... is employed by a for-profit company with an interest in the subject of the presentation, ... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented