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IOP measurement from corneal vibrations parameters analysis enables sex-specific non-contact tonometry

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First Author: R.Davidson USA

Co Author(s):    P. Bitoun                    

Abstract Details

Purpose:

To describe the use of a non-contact vibrometer for the measurement of intraocular pressure and to demonstrate that the results represent a sex-specific pattern associated with actual intraocular pressure.

Setting:

Robert Ballanger Hospital, France Paris Glaucoma Institute, France

Methods:

Informed consent was obtained from local IRB History, Refractometry, keratometry and pachymetry were performed on each eye Triplicate corneal vibration tonometry was performed on 636 eyes from 321 patient volunteers from multiple ethnic origins Triplicate Goldmann Applanation Tonometry was also performed to act as the reference value A Non-linear regression model of IOP prediction was used Average of 2 closest IOP predicted values was used for analysis Principal component analysis was performed to identify the strongest factors correlating to IOP

Results:

636 eyes from 321 patients were measured. 156 (48.7%) female, 165 (51.3%) male Age 20-92 years Goldmann Applanation Tonometry Mean IOP was 15.88 in women and 15.78 mmHG in men Vibrometry measurements for women: 98.7% of IOP mean was within 5 mmHG of mean Goldmann Applanation Tonometry IOP Vibrometry measurements for men: 98.4% of IOP mean was within 5 mmHg of mean Goldmann Applanation Tonometry IOP In women: Pearson correlation coefficient was 0.786 In men: Pearson correlation coefficient was 0.799 The algorithm that correlates the acoustic response of the cornea were different in men and women

Conclusions:

Corneal vibration tonometry measurement seems to be a safe and clinically feasible and valuable method of calculating IOP and allows multiple fast repeated measurements with good reproducibility. Algorithms differ according to subject's sex, thus reflecting sensitivity to corneal elasticity differences

Financial Disclosure:

... gains financially from product or procedure presented