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Correlation between optical quality and corneal biomechanics in patients with keratoconus

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First Author: A.Yamakawa JAPAN

Co Author(s):    S. Koh   R. Inoue   R. Ambrósio   A. Miki   N. Maeda   K. Nishida     

Abstract Details

Purpose:

To assess correlations between the corneal biomechanical indices, determined by Scheimpflug-based corneal biomechanical assessments, and the optical quality, assessed as higher-order aberrations (HOAs) using wavefront sensor in patients with keratoconus (KC).

Setting:

Osaka University Hospital, Osaka, Japan

Methods:

Corneal biomechanical assessments using Corvis ST (Oculus), and HOAs measurements using a wavefront sensor (KR-1W; Topcon) were performed in eyes with KC and KC suspect (KCS). Correlations between biomechanical indices and ocular HOAs were assessed. Corneal biomechanical indices included the deformation amplitude max 2 mm (DAR2mm), integrated radius (IR), stiffness parameter at the first applanation (SPA1), and the linear Corvis Biomechanical Index (CBI beta). From the wavefront data of the 4-mm purpil , the magnitudes of trefoil, coma, tetrafoil, secondary astigmatism, and spherical aberration were calculated by Zernike vector analysis, and used as ocular HOAs parameters along with total HOAs.

Results:

Thirty-four KC eyes and 37 KCS eyes were included. All the corneal biomechanical indices were significantly correlated with total HOAs and all the Zernike vector components. In particular, greater correlations were observed between total HOAs and coma. Of all biomechanical indices, CBI beta showed the highest correlation with wavefront parameters.

Conclusions:

Corneal biomechanical indices correlated with ocular HOAs in patients with KC. In particular, there was a strong association with the increase in coma caused by a superior–inferior asymmetry of the shape of the cornea in patients with KC.

Financial Disclosure:

... is employed by a for-profit company with an interest in the subject of the presentation, ... travel has been funded, fully or partially, by a company producing, developing or supplying the product or procedure presented, ... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented