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Donor gender and donor with history of radio or chemotherapy as risk factors for delayed corneal epithelialization after keratoplasty
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First Author: M.Ahad SAUDI ARABIA
Co Author(s): D. Jamal D. Milibari
Abstract Details
Purpose:
To identify donor and recipient risk factors that may lead to delayed corneal epithelialization after routine optical, penetrating or lamellar keratoplasty.
Setting:
Retrospective case review study performed at a tertiary eye hospital
Methods:
It was a retrospective study of all patients who underwent keratoplasty between June 2014 to February 2019 at our hospital. Eyes undergoing either penetrating (PKP) or lamellar keratoplasty (LKP) that failed to re-epithelialize within 7 days with medical treatment were identified. Exclusion criteria was age less than 18 years, or keratoplasty for therapeutic or tectonic reasons. Demographic details, ocular, intra-operative, donor and postoperative data were collected. Factors either related to donors, host, operation or post-operative management that could potentially delay epithelialization, were specifically analyzed
Results:
146 cases that fulfilled the criteria were included in the study. 77 (52.7%) eyes underwent PKP and 69 eyes (48.3%) LKP. The mean age was 44 years (range 18-111). The most common indication for keratoplasty was corneal ecatsia (58.8%) followed by corneal opacity (15.1%). In multivariate model: Recipients with vernal keratoconjunctivitis (P < 0.000), donor-recipient gender mismatch (P< 0.03) and donors having received previous radio- or chemotherapy for any carcinoma (P< 0.013) were significant risk factors for delayed epithelialization. It was also noted that when the donor gender was female, epithelialization was delayed irrespective of recipient gender.
Conclusions:
This study showed that vernal keratoconjunctivitis, donor-recipient gender miss-match, and donors having received radiotherapy or chemotherapy for any carcinoma were significant risk factors for delayed corneal epithelialization after lamellar and penetrating keratoplasty for elective indications.
Financial Disclosure:
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