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Comparison of postoperative haze in photorefractive keratectomy among patients with low myopia and ablation depth of less than 70 micron with and without mitomycin C application

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First Author: N.Nassiri IRAN

Co Author(s):    K. Sheibani   S. Kavousnezhad                 

Abstract Details

Purpose:

To evaluate the safety and efficacy of 5 seconds of mitomycin C (MMC) application during photorefractive keratectomy (PRK) with ablation depth of less than 70 Micron among patients with low myopia.

Setting:

Vanak Eye Clinic, Tehran, Iran.

Methods:

In this prospective randomized double masked controlled clinical trial, patients with low myopia (less than three diopter) and an ablation depth of less than 70 micron who were candidate for PRK in both their eyes were recruited. One eye of each patient included in the study randomly received intraoperative topical MMC 0.02% for 20 to 30 seconds or placebo. The main outcome measure was postoperative corneal haze development during six months after PRK based on confocal microscopy findings.

Results:

Seventy eyes from thirty five patients randomly assigned to mitomycin or control groups were evaluated in this study. There was no statistically significant difference between the case and control groups regarding the mean preoperative age, sex, best corrected visual acuity, uncorrected visual acuity, sphere, cylinder, spherical equivalent, intraocular pressure or endothelial cell count. The mean haze based on confocal microscopy readings six months postoperatively was significantly lower in the group receiving mitomycin (p=0.003). The mean endothelial cell density was not significantly different between the MMC group and the control group postoperatively (P=0.006).

Conclusions:

Based on our findings application of MMC 0.02% reduces the haze formation even in eyes with low myopia undergoing PRK with an ablation depth of less than 70 micron compared with placebo up to 6 months postoperatively without a significant effect on endothelial cell count.

Financial Disclosure:

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