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Long-term capsular bag clarity of a new fluid-filled, modular accommodating intraocular lens

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First Author: L.Werner USA

Co Author(s):    S. Bontu   S. Kennedy   K. Kamae   B. Jiang   D. Brady   N. Mamalis     

Abstract Details

Purpose:

To evaluate the capsular biocompatibility of a new accommodating intraocular lens (IOL), consisting of base and fluid lenses, in the rabbit model during 6 months (24 weeks). In this accelerated in vivo model, 6 weeks correspond to approximately 2 years in humans in terms of posterior capsule opacification (PCO) formation.

Setting:

John A. Moran Eye Center, University of Utah.

Methods:

Bilateral phacoemulsification was performed on 8 rabbits; one eye received the test lens (Juvene, LensGen) and the other a hydrophobic acrylic control lens (SA60AT, Alcon). Slit lamp examinations were performed at different points up to 6 months. The rabbits were then sacrificed, with pathological evaluation. In another study with 5 rabbits, ease of explant/exchange of the fluid lens, or fluid and base lenses was also assessed.

Results:

Uveal biocompatibility was similar between test and control lenses up to six months postoperatively. Anterior capsule opacification appeared absent in the test group, and PCO was significantly less in comparison to the control group throughout the study. At the gross examination at 6 months, central PCO was scored as 0.12 +/- 0.23 with test lenses, and as 4.0 +/- 0 with control lenses (P less than 0.0001 two-tail; Paired T-Test). Histopathology confirmed the relative lack of fibrosis in the test group. The overall capsular bag clarity of the test lenses reduced the complexity of explant/exchange procedures.

Conclusions:

The Juvene maintains an open and expanded capsular bag with aqueous humor circulation, without significant contact with the anterior capsule edge. This prevents overall capsular bag opacification/fibrosis while retaining uveal biocompatibility. Its modular design allows for easy exchange of the fluid lens and/or base lens, if necessary.

Financial Disclosure:

... is employed by a for-profit company with an interest in the subject of the presentation, ... research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented