Posters

Effect of antiglaucomatous drops which reduced the aqueous humor production on bacterial growth potential in rabbit eyes

Poster Details

First Author: M. Batur TURKEY

Co Author(s): M. Parlak   E. Seven   S. Tekin   T. YaaŸar           

Abstract Details

Purpose:

To evaluate the bacterial growth potential and endophthalmitis ratio following usage of dorzolamide 20 mg/ml and timolol 5 mg/ml drop in rabbit eyes that bacteria inoculated into anterior chamber.

Setting:

Yuzuncu Yil University, Medical Faculty, Department of Ophthalmology

Methods:

Five New Zealand rabbits weighing 3 to 3.5 kg were used. Dorzolamide + timolol (Cosopt® 20 mg/ml + 5 mg/ml) was dropped into the right eyes and placebo (Eyestil® hyaluronic acid) was dropped into the left eyes of each rabbit 12 hour intervals twice. Two hours after second drops, the right and left eyes of each rabbit was inoculated with 3750 colony-forming units of Staphylococcus aureus into the anterior chamber. Same drops were continued twice daily for three days in the same way.

Results:

In sample that taken at the 24th hour, bacterial growth occured in 3 of 5 eyes of dorzolamide + timolol group. There was no bacterial growth in the placebo eyes. According to endophthalmitis grading scheme, the results of dorzolamide + timolol and placebo groups were 1.25 ± 0.79, 0.6 ± 0.49 (p = 0.176) for the 24th hour, 1.75 ± 1.13, 0.45 ± 0.48 (p = 0.038) for the 48th hour and 1.40 ± 1.19 , 0.40 ± 0.65 (p = 0.066) for the 72th hour, respectively.

Conclusions:

Usage drugs which reduce the humor aqueous can increase the risk of the bacterial growth potential and endophthalmitis. Following the anterior segment surgery it is well known condition to found bacteria in humor aqueous. When these drugs are used before the surgery, attention should be paid. The studies that have more cases are required.

Financial Disclosure:

None