Meta-analysis of post-operative outcome parameters comparing Descemet's membrane endothelial keratoplasty (DMEK) vs Descemet's stripping automated endothelial keratoplasty (DSAEK)
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Session Details
Session Title: Moderated Poster Session: Miscellaneous
Session Date/Time: Saturday 11/02/2017 | 13:00-14:15
Paper Time: 13:48
Venue: Poster Area
First Author: M. Shajari GERMANY
Co Author(s): I. Pavlovic E. Herrmann I. Schmack A. Lencova T. Kohnen
Abstract Details
Purpose:
This meta-analysis compares Descemet Membrane Endothelial Keratoplasty (DMEK) to Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) in order to evaluate their strengths and weakness profiles.
Setting:
Frankfurt University, Germany
Methods:
We systematically searched the peer-reviewed literature in PubMed (04.07.2016 – 26.09.2016), Cochrane Library (25.07.2016 – 26.09.2016), Web of science (29.07.2016 - 26.09.2016), Embase (07.08.2016 - 26.09.2016) according to PRISMA guidelines. Only prospective and retrospective trials, which performed DMEK as well as DSAEK and compared both procedures, were included. The effects were calculated as odds ratios or standardized mean differences.
Results:
A total of 10 studies with a total of 523 eyes (250 DMEK; 273 DSAEK) were included. No significant difference was found in terms of total detachment rate (P=0.28); graft failure (P=0.18); graft rejection (P=0.37) and endothelial cell loss (P=0.48). There was a significantly higher partial detachment rate with DMEK (P<0.001). DMEK was superior in terms of best corrected visual acuity after 6 months (P<0.001); subjective visual evaluation (P=0.001); patient satisfaction (P<0.001) and preferred method by patient (P=0.001)
Conclusions:
DMEK and DSAEK have a similar complication profile. However, the higher rate of partial detachment in DMEK is easy to manage by rebubbling and the clear superiority in visual outcome and patient satisfaction makes it the treatment of choice when corneal endothelial keratoplasty has to be performed.
Financial Disclosure:
None
