Evaluation of efficacy and safety of mitomycin C application in laser-assisted subepithelial keratectomy (LASEK)

Session Details

Session Title: Refractive
Session Date/Time: Friday 10/02/2017 | 10:30-12:30
Paper Time: 11:48
Venue: Brussels Room 0.4

First Author: E. Chynn USA
Co Author(s): J. Guo  T. Bakaeva              

Abstract Details

Purpose:

(1)To evaluate whether low dose (0.01%) application of intraoperative Mytomycin-C (MMC) is effective in postoperative corneal haze prevention, (2) to evaluate if a low duration is as effective as a variable duration of MMC application and (3) to evaluate if varying MMC application time affects recovery time after LASEK.

Setting:

Park Avenue LASEK

Methods:

206 patients underwent LASEK for myopia, hyperopia and/or astigmatism.All right eyes received a 10sec 0.01% MMC intraoperatively. All left eyes served as a control and received 0.01% MMC for 0-80 sec varying based on refractive error:SE of -5.00 to +2.00D received no MMC,myopic SE>5.00D or cyl>3.00 D received 0.01% MMC for a duration equal to the ablation time,hyperopic SE>2.00 D received 0.01% MMC for half of the ablation time.A total of 49 left eyes received MMC.Recovery time was assessed by measuring time to intended refraction.41 patients by a questionnaire quantifying peak pain day,pain grade,days to pain free.

Results:

206 eyes treated with 0.01% MMC after LASEK, 18 eyes developed trace to 1+ haze,10 were right eye with 10sec of MMC application,8 eyes were left eye with MMC application depending on ablation time.Our results indicated that there is no statistically significant difference in haze formation between both protocols (p=0.0194) or difference between the mean times needed to reach the intended postoperative refraction which indicates there is no correlation between MMC application time and time needed to reach intended refraction.There is no significant difference in pain grade between both groups and or the duration of MMC application.

Conclusions:

Development and grade of haze as well as time needed to reach intended postoperative refraction were not dependent on the duration of intraoperative MMC. Duration of MMC did not delay epithelial healing or affect the level of discomfort in post-LASEK patients.

Financial Disclosure:

None