Limbal stem cell deficiency (LSCD): demographics and clinical features of a large case series

Session Details

Session Title: Cornea: Medical

Session Date/Time: Tuesday 10/10/2017 | 08:00-10:30

Paper Time: 10:06

Venue: Room 3.6

First Author: : E.Sarnicola ITALY

Co Author(s): :    N. Auteri   B. Genereux   L. Sepsakos   A. Cheung   E. Holland        

Abstract Details

Purpose:

To describe the clinical features and etiologies of patients with LSCD

Setting:

Cincinnati Eye Institute, Cincinnati, Ohio, USA.

Methods:

Retrospective charts analysis of 738 eyes of 432 patients that were diagnosed with LSCD at a tertiary referral center between 2002 and 2015. Outcome measures included patient demographics, LSCD etiologies, laterality, coexisting ocular diseases, and performed surgical procedures.

Results:

Mean patient age at the first visit was 62 years (range 2-91) and 221 patients were male whereas 211 were female. Diagnosis was bilateral in 70% of the patients. Mean visual acuity at the first visit 20/80 (range NLP-20/20). The main LSCD etiologies were aniridia/variant aniridia (31%), ocular burn (21%), contact lens (17%), Steven-Johnson syndrome (10%), and iatrogenic (6%). Eighty eyes had a hystory of previous failed keratoplasty without ocular surface transplant (OSST). Mean follow-up was 68±55 months. OSST was performed in 251 eyes(34%), and Boston keratoprosthesis in 62 eyes(8%). Cataract (37%) and glaucoma(33%) were the most frequent comorbidities.

Conclusions:

LSCD is a heterogeneous disease secondary to a broad number of etiologies, and it is often under-diagnosed. This study reports novel data about demographics and clinical feature

Financial Disclosure:

NONE